Amphetamines - A Medical Dictionary, Bibliography, and by Health Publica Icon Health Publications

By Health Publica Icon Health Publications

This can be a 3-in-1 reference booklet. It offers a whole clinical dictionary masking countless numbers of phrases and expressions in terms of amphetamines. It additionally provides vast lists of bibliographic citations. ultimately, it offers details to clients on how one can replace their wisdom utilizing numerous web assets. The booklet is designed for physicians, clinical scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to get to grips with examine devoted to amphetamines. in case your time is effective, this booklet is for you. First, you won't waste time looking the web whereas lacking loads of suitable info. moment, the e-book additionally saves you time indexing and defining entries. eventually, you won't waste time and cash printing thousands of web content.

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In my proposal, I build on recent studies by our laboratory on DAT-1 to: 1) determine the expression level and localization of DAT-1, 2) characterize the interactions of the C. 22) with DAT-1 and, 3) identify novel proteins that interact with the C. elegans dopamine transporter. These studies will increase our understanding of intrinsic modulatory influences controlling DA signaling in vivo and in disease states. S. db=Pmc, and type “amphetamines” (or synonyms) into the search box. This search gives you access to full-text articles.

Our recent studies suggest that besides the role of dopamine in the action of psychostimulants, nitric oxide (NO) may play a pivotal role in mediating the effects of these drugs. In brain, NO is produced by the neuronal, inducible and endothelial nitric oxide synthase isoforms (nNOS, iNOS, eNOS) and has been implicated in neural transmission, plasticity and neurotoxicity. We 32 Amphetamines hypothesize that nNOS has a major role in 1) the psychomotor stimulating effects, 2) the reinforcing properties and 3) the dopaminergic neurotoxicity produced by substituted amphetamines.

The primary objective of the present study is the design and synthesis of conformationally-restricted derivatives of fluoxetine, as potential pharmacologically active compounds. Both (R) and (S)-fluoxetine are flexible molecules. The (S)-isomer displays prolonged duration in man, which may contribute to side effects. Flexible molecules may have more than one site of action, with one preferred conformation at the receptor site. Side effects observed may be due to a low-energy conformation of fluoxetine at a second site.

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