By Gareth Adamson
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Bone Miner. Metab. 19, 201–206. , et al. (2006). VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection). Circulation 113, 1615–1621. Weintraub, M. , and Breslow, J. L. (1987). Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E. J. Clin. Invest. 80, 1571–1577. , and Prentice, A. (2004). Vitamin K status of older individuals in northern China is superior to that of older individuals in the UK.
1987). Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E. J. Clin. Invest. 80, 1571–1577. , and Prentice, A. (2004). Vitamin K status of older individuals in northern China is superior to that of older individuals in the UK. Br. J. Nutr. 92, 939–945. , and Prentice, A. (2005). Effect of apolipoprotein E genotype on vitamin K status in healthy older adults from China and the UK. Br. J. Nutr. 94, 956–961. , and Irahara, M. (2006). Undercarboxylated osteocalcin concentration in postmenopausal women receiving hormone therapy daily and on alternate days.
K > O) to form reduced vitamin K (vit. K1H2), the essential cofactor for g-carboxylation of vitamin K-dependent proteins. Adapted from Wajih et al. (2007, Fig. 9, p. 2633). therapy to reduce the side effects is appealing, especially as warfarin remains the drug of choice for anticoagulation treatment. , 2005). Both enantiomers block VKORC1 activity, and consequently vitamin K recycling. Studies of the pharmacodynamics and pharmacokinetics of warfarin have revealed several environmental and genetic factors which may determine the variability of dose.