BioMEMS and Biomedical Nanotechnology: Volume I Biological by Jun Li, M. Meyyappan (auth.), Mauro Ferrari Ph.D., Abraham

By Jun Li, M. Meyyappan (auth.), Mauro Ferrari Ph.D., Abraham P. Lee, L. James Lee (eds.)

Abe Lee has been engaged on micro/ and nanotechnology for biomedical and biotech purposes considering 1992. His contemporary examine specializes in the improvement of built-in micro and nano fluidic chip processors for the subsequent functions: point-of-care diagnostics, "smart" nanomedicine for early detection and therapy, stem phone biology and therapeutics, the synthesis of novel and natural fabrics, and biosensors to notice environmental and terrorism threats. He has over 30 peer reviewed guides and over 30 issued US patents. i'm additionally topic editor for the magazine of Microelectromechanical platforms and member of the foreign Advisory Editorial Board for the Lab on a Chip journal.

Jim Lee's learn curiosity contains BioMEMS/NEMS, and polymer micro/nanotechnology. within the final four years, he has over 20 refereed magazine guides, 2 e-book chapters, and five patents in those components. he's now top an NSF Nanoscale technological know-how and Engineering heart for reasonable Nanoengineering of Polymer Biomedical units at OSU.

Professor Mauro Ferrari is a pioneer within the fields of bioMEMS and biomedical nanotechnology. As a number one educational, a committed entrepreneur, and a imaginative and prescient setter for the Nation's ideal Federal courses in nanomedicine, he brings a three-fold vantage point of view to his roles as Editor-in-Chief for this paintings. Dr. Ferrari has authored or co-authored over a hundred and fifty clinical courses, 6 books, and over 20 US and

International patents. Dr. Ferrari can also be Editor-in-Chief of Biomedical Microdevices and sequence editor of the hot Springer sequence on rising Biomedical Technologies.

Several inner most quarter businesses originated from his laboratories on the Ohio country collage and the college of California at Berkeley through the years. On a Federal project as detailed

Expert in Nanotechnology and Eminent pupil, he has supplied the clinical management for the advance of the Alliance for melanoma Nanotechnology of the nationwide melanoma Institute, the world-largest scientific nanotechnology operation up to now. Dr. Ferrari educated in mathematical physics in Italy, acquired his Master's and Ph.D. in Mechanical

Engineering at Berkeley, attended scientific tuition on the Ohio kingdom collage, and served in college positions in fabrics technological know-how and Engineering, and Civil and Environmental Engineering in Berkeley, the place he was once first tenured. At Ohio country he presently serves as Professor of inner medication, department of Hematology and Oncology, as Edgar Hendrickson Professor of Biomedical Engineering, and as Professor of Mechanical Engineering. he's affiliate Director of the Dorothy M. Davis

Heart and Lung learn Institute, and the University's affiliate vice chairman for well-being technological know-how, expertise and Commercialization.

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Extra info for BioMEMS and Biomedical Nanotechnology: Volume I Biological and Biomedical Nanotechnology

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There have been several reports of fabrication of uniform biodegradable polymer microspheres [4–5, 105, 152, 159]. Amsden and Goosen have used electrostatics to form EVAc spheres with diameters smaller than the nozzle from which they were sprayed [5]. ” Amsden later reported production of uniform microspheres by extruding a polymer solution through a nozzle and into a stabilizing solution flowing perpendicular to the point of injection [3]. The PLG solution droplets exiting the nozzle are drawn into the PVA solution in a periodic fashion.

The ability of APCs to phagocytose particulates is dependent on the particle size. In particular, 1- to 10-µm diameter microspheres are optimally taken up by APCs in a number of tissues [9] and have been shown to enhance antigen-specific T-helper lymphocyte (Th) responses [142] (thus leading to an enhancement in antigen-specific antibody responses) and elicit a cytotoxic T lymphocyte (CTL) response (Nixon et al. 1996). T-cell activation in response to antigen-encapsulating microspheres has been shown to be 100-1000 fold better than antigen alone [179].

Thus AC voltammetry will be the ideal technique for biosensors based on nanoelectrode array. 3. Functionalization of Oligonucleotide Probes As mentioned earlier, the oxides at the CNT ends can be converted to carboxylic groups using EC etching. A ferrocene (Fc) derivative, Fc(CH2 )2 NH2 , can be selectively functionalized at the tube ends through amide bonds facilitated by the coupling reagents dicyclohexylcarbodiimide (DCC) and N-hydroxysuccinimide (NHS) [13] as illustrated in Fig. 10(a). ATGCCTTCCys O DNA probe O SO3Na O –N ...

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